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Current Neurosurgery Research

The following research studies are available.  For further information contact us at 630-978-6770.

Basal ganglia physiology in humans undergoing surgery for movement disorders

Electrical recordings made from single brain cells during surgery to confirm accurate electrode placement are later studies for abnormal patterns in order to gain further understanding of the underlying pathology in various movement disorders.

Treatment of dystonia with deep brain stimulation

In this investigational study, we perform electrical recordings from a region of the brain called the basal ganglia that is thought to be involved in the pathophysiology of dystonia.  The goal of the study is to gain a better understanding of the underlying abnormality of the cellular electrical activity in this region.  Furthermore, we are interested in determining the clinical effectiveness of deep brain stimulation after implantation to determine the outcome of this procedure in relation to dystonia types and programming settings, particularly in the pediatric dystonia population.

Treatment of refractory cluster headache with deep brain stimulation

In patients with cluster headache that is severe and refractory to all forms of medical therapy, deep brain stimulation may be of significant benefit.  To date, approximately 60 patients have been treated by placing a deep brain stimulation electrode in an area of the brain called the posterior hypothalamic region.  Long-term results of this therapy have shown significant success in 50-60% of patients.  We are interested in understanding the mechanism of deep brain stimulation action as well as delineating which patients are likely to be successful candidates for this therapy. 

Deep brain stimulation for the treatment of depression

This is a pilot study investigating the role of deep brain stimulation in treating patients suffering from severe depression who are refractory to all medical therapy as well as electroconvulsive therapy.

Deep brain stimulation for the treatment of obesity in the primate

This study investigates the effects on deep brain stimulation in a novel region of the brain that has affects on weight, food intake, and hormone profile in an obese model of the primate.  The goal of this investigation is to determine the safety and effectiveness of deep brain stimulation for treating severe obesity in humans.