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Home > Health & Fitness > Healthwise > Leukotriene Pathway Modifiers for Long-Term Control of Asthma
These medicines are available as pills and chewable
Leukotriene pathway modifiers improve
lung function and decrease
Leukotriene pathway modifiers are
used to treat people with persistent asthma who need daily medicine to
control inflammation of the airways leading to the lungs
These medicines may be given along with
corticosteroids to control
mild persistent and moderate persistent asthma. They
may be especially helpful for people whose asthma is triggered by exercise,
aspirin, or allergies.
Different types of medicines are often
used together in the treatment of asthma. Treatment for asthma
depends on a person’s age, his or her type of asthma, and how well the
treatment is controlling asthma symptoms.
Your doctor will work with you to help find the number and
dose of medicines that work best.
Research shows that compared
placebo, leukotriene pathway modifiers:
But leukotriene pathway modifiers are not as effective
as inhaled corticosteroids. And adding leukotrienes to inhaled corticosteroids
is not as effective as adding long-acting beta2-agonists to inhaled
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Common side effects of this medicine include:
Leukotriene pathway modifiers can cause more serious problems such as mood changes, depression, hallucinations, and suicidal thinking, but this is rare.
In rare cases, zafirlukast and zileuton cause
liver damage. If the liver is being affected by zafirlukast or zileuton, liver
function tests will show increased liver enzyme levels in the blood, usually
within the first 2 months of treatment.
Montelukast causes fewer
side effects than other leukotriene pathway modifiers. It is less likely to
affect the liver, so liver function monitoring is not needed.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
The U.S. National Asthma
Education and Prevention Program (NAEPP) recommends leukotriene pathway
modifiers as an alternative treatment for people who have mild or persistent asthma.
Preferred medicines are inhaled corticosteroids with or without long-acting
People who take
zafirlukast and medicine to prevent blood clots (such as warfarin) need to
have their clotting times checked regularly. When used with blood-thinning
medicine, zafirlukast can increase the risk of bleeding. Zafirlukast also may
cause problems when taken with other medicines, such as blood pressure
medicines, aspirin, and some seizure medicines. Before you take zafirlukast, make sure your doctor knows
that you are taking any of those medicines.
Montelukast can be given to people age 2 and older. It is given once a
day. Zafirlukast can be given to people age 5 and older. It is given twice a
day. Zileuton has not been approved by the U.S. Food and Drug Administration
(FDA) for use in children.
People who are taking zafirlukast or
zileuton need to have liver function tests several times during the first 6
months of treatment. People who are taking theophylline along with zileuton may
need to take less theophylline.
People who take leukotriene
pathway modifiers may be more likely to take their medicine regularly, because
it can be taken orally and has a more immediate effect on symptoms than some
other medicines such as inhaled corticosteroids.
pathway modifiers are not used to treat
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
If you are pregnant, breast-feeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
Dennis RJ, et al. (2010). Asthma in adults, search date June 2008. Online version of BMJ Clinical Evidence: www.clinicalevidence.com.
Keeley D, McKean M (2006). Asthma and other wheezing disorders in children, search date October 2005. Online version of BMJ Clinical Evidence: http://www.clinicalevidence.com.
National Institutes of Health (2007). National Asthma Education and Prevention Program Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma (NIH Publication No. 08–5846). Available online: http://www.nhlbi.nih.gov/guidelines/asthma/index.htm.
February 13, 2011
E. Gregory Thompson, MD - Internal Medicine & Rohit K Katial, MD - Allergy and Immunology
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