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Zollinger-Ellison syndrome is a rare condition in which a tumor
called a gastrinoma forms in the pancreas or small intestine. The tumor
releases a hormone called gastrin that causes production of excess stomach
Almost all people who have Zollinger-Ellison syndrome get an ulcer at
some point, usually in the small intestine (duodenal ulcer). Ulcers produced by
this disease are more difficult to cure than ulcers from other causes.
In about half of the people with Zollinger-Ellison syndrome, the
tumors (gastrinomas) are cancerous and can spread to the lymph nodes and
The main treatment for Zollinger-Ellison syndrome is removal of the
tumors and taking acid-suppressing medicine called proton pump
Current as of:
November 20, 2015
E. Gregory Thompson, MD - Internal Medicine & Adam Husney, MD - Family Medicine & Jerome B. Simon, MD, FRCPC, FACP - Gastroenterology
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