Skip to Content

Sepehr B. Sani, MD - Neurosurgeon

Sepehr B. Sani, MD

Request Appointment Online

To schedule an appointment with Sepehr B. Sani please call 312-942-6644.


Year began practicing:
Year joined staff:


  • Surgery - Neurological
  • Surgery - Spine

Areas of Interest

Deep brain stimulation, Parkinson's disease, Essential tremors, Dystonia, Depression, Obsessive Compulsive Disorder, Tourette syndrome, Epilepsy, Epilepsy surgery, Temporal lobectomy, Lobar resection, Corpus callosotomy, Hemispherectomy, Vagan nerve stimulation


  • Independent Practitioner


Medical School

Medical College of Ohio, Toledo, Ohio


Rush University Medical Center, Chicago, Illinois


Rush University Medical Center, Chicago, Illinois


Rush University Medical Center, Chicago, Illinois
University of California, San Francisco, California

Board Certifications

  • Neurological Surgery

Special Practices & Procedures

  • Minimally invasive cranial procedures for brain tumors and epilepsy
  • Deep brain stimulation for the treatment of movement disorders including Parkinson's disease, essential tremor, dystonia, and psychiatric disorders including severe depression, obsessive compulsive disorder and Tourette Syndrome.

What Patients Are Saying

I received excellent service from both Dr. Sani and his staff. I felt very comfortable with Dr. Sani's explanation of my condition. It gave me a lot of confidence in him.

Dr. Sani is very knowledgeable, professional and shows genuine concern.

I cannot say enough about the care I received from Dr. Sani and his staff. Everyone in his office is excellent. Although I pray I will not need his service again, I would not have any concerns about seeing Dr. Sani again.

I am very pleased with Dr. Sani. He is approachable, friendly and extremely kind. The staff seemed most efficient.

Dr. Sani is the consummate professional and still relates personally very well. I would recommend him to any and all with the highest regard.

Dr. Sani is the most even tempered and courteous doctor we have ever met. Wonderful man – Better doctor!


As an independent physician practitioner, this physician is not an agent or employee of Rush-Copley Medical Center, Inc. or any of its affiliated entities. This physician has chosen Rush-Copley Medical Center, Inc. or its affiliated facilities as a place to treat and care for his or her patients.

Physician Bio

Dr. Sepehr Sani specializes in neurosurgery. Neurosurgical care is available to patients in the Fox Valley and Dr. Sani offers academic-level expertise close to home. Issues affecting the brain are often complex, Dr. Sani demystifies the terms and provides patients with a thorough understanding of their condition. He also has a special interest in treating movement disorders including Parkinson’s Disease.

Recent Publications

Sani S, Ostrem JL, Shimamoto S, Levesque N, and Starr PA, Single Unit “Pauser” Characteristics of the Globus Pallidus Pars Externa Distinguish Primary Dystonia from Secondary Dystonia and Parkinson’s Disease.  Experimental Neurology. Submitted.

Sani S, Shimamoto S, Turner RS, Levesque N, and Starr PA.  Microelectrode Recording in the Posterior Hypothalamic Region in Humans.  Operative Neurosurgery. Accepted

Sani S, Boco T, Lewis SL, Cochran E, Patel AJ and Byrne RW.   Post-operative acute disseminated encephalomyelitis after exposure to Avitene® – a case report.  J Neurosurgery. In press.

Sani S, Smith AP, Kanner A, Smith M and Byrne RW.  Medically Intractable Temporal Lobe Epilepsy in Patients with Normal MRI: Surgical Outcome in twenty four consecutive patients.  Neurosurgery. Submitted.

Sani S, Jobe KW, Smith AE, Kordower J, Bakay RAE.  Chronic bilateral deep brain stimulation of the rat lateral hypothalamus leads to significant and sustained weight loss.  J Neurosurgery. 107(4):809-13; 2007.

Sani S and Medhkour A. Olfactory groove meningiomas: Psychiatric symptoms foster delayed diagnosis. Resident & Staff Physician. 52(2):13-18; 2006.

Rayport M, Sani S, Ferguson SM. Olfactory Gustatory Responses Evoked by Electrical Simulation of Amygdalar Regin in Man are Qualitatively Modifiable by Interview Content: Case Report and Review  Rev Neurobiol. 76:35-42; 2006.

Musacchio M, Kuchay B, Patel N, Sani S, Lopes D.  Long-Term Follow-Up of Quality of Life after Gamma Knife Radiosurgery Treatment for Arteriovenous Malformations.  Radiosurgery. 6:211-20; 2006.

Sani S, Traul D, Klink A, Niaraki N, Gonzalo-Ruiz A, Wu CK, and Geula C. Distribution, progression and chemical composition of cortical amyloid-beta deposits in aged rhesus monkeys: similarities to the human.  Acta Neuropathologica. 105(2):145-56, 2003.

Office Information